Reactivation of Resolved Hepatitis B After Daratumumab for Multiple Myeloma

The risk of reactivation of resolved hepatitis B virus (HBV) in hepatitis B surface antigen (HBsAg)-negative multiple myeloma patients after daratumumab has not been reported. Among 93 patients with daratumumab treatment, reactivation occurred in 6 patients (6.5%) with one hepatic failure. This is the first report demonstrating a considerable risk of reactivation of resolved HBV after daratumumab.

Automated summary

Among multiple myeloma patients who are HBsAg-negative and receiving daratumumab treatment, there is a significant risk of reactivation of resolved HBV.