4.7 Article

First-in-Human Phase I Study of ABBV-085, an Antibody-Drug Conjugate Targeting LRRC15, in Sarcomas and Other Advanced Solid Tumors

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Article Oncology

ABBV-085, Antibody-Drug Conjugate Targeting LRRC15, Is Effective in Osteosarcoma: A Report by the Pediatric Preclinical Testing Consortium

Pooja Hingorani et al.

Summary: The membrane protein LRRC15 is expressed in solid tumors, including osteosarcoma. The antibody-drug conjugate ABBV-085, targeting LRRC15, showed antitumor activity in osteosarcoma PDX models, inhibiting tumor growth in six out of seven models and improving event-free survival in five models. These findings suggest LRRC15 as a promising target for clinical trials in osteosarcoma patients.

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