4.5 Review

Monoclonal free light chain detection and quantification: Performances and limits of available laboratory assays

期刊

CLINICAL BIOCHEMISTRY
卷 95, 期 -, 页码 28-33

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.clinbiochem.2021.05.006

关键词

Free light chains; Laboratory methods; Electrophoresis; Mass spectrometry; Monoclonal gammopathy

向作者/读者索取更多资源

The detection and quantification of immunoglobulin free light chains is crucial for the diagnosis and monitoring of monoclonal gammopathies. Despite improvements in quality and efficiency of tests available in clinical laboratories, results remain variable. This review article focuses on analyzing techniques like mass spectrometry that could potentially replace current methods.
The detection and quantification of immunoglobulin free light chains in serum and urine is recommended for the diagnosis and monitoring of monoclonal gammopathies according to the guidelines of the International Myeloma Working Group (IMWG). Several tests are currently available in the clinical laboratory to detect and quantify free light chains but although quality, efficiency, and effectiveness have been improved, the results are still variable and poorly harmonized and standardized. The present review article wants to analyze these aspects, with a keen eye on techniques, such as mass spectrometry, that could replace in the practical clinical laboratory the current methods including Bence-Jones protein assay and free light chain immunoassays.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据