Spheroplasts, poorly known but clinically relevant particles of urinary sediment

Background: In two patients under treatment with various antibiotics, spheroplasts were detected with an automated urine sediment analyzer. Methods: Urinalysis was performed by an AutionMAX AX 4030-sediMAX platform. Results: Spheroplasts can be easily misclassified as yeasts or erythrocytes, but when automated urine sediment analyzers are used by well-trained, and experienced operators they can be correctly identified and classified. Conclusion: Appropriate training of urine laboratory professionals in spheroplast detection and association with UTI, together with timely communication with the microbiologist and caring clinician, will provide prompt targeted treatment.

Automated summary

Spheroplasts can be easily misclassified as other components in urine sediment, but can be correctly identified and classified by well-trained professionals using automated urine sediment analyzers. This can lead to prompt targeted treatment for urinary tract infections.