4.7 Article

Spheroplasts, poorly known but clinically relevant particles of urinary sediment

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CLINICA CHIMICA ACTA
卷 515, 期 -, 页码 13-15

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ELSEVIER
DOI: 10.1016/j.cca.2020.12.026

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Spheroplasts; beta-lactam antibiotics; SediMAX; Urinalysis

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Spheroplasts can be easily misclassified as other components in urine sediment, but can be correctly identified and classified by well-trained professionals using automated urine sediment analyzers. This can lead to prompt targeted treatment for urinary tract infections.
Background: In two patients under treatment with various antibiotics, spheroplasts were detected with an automated urine sediment analyzer. Methods: Urinalysis was performed by an AutionMAX AX 4030-sediMAX platform. Results: Spheroplasts can be easily misclassified as yeasts or erythrocytes, but when automated urine sediment analyzers are used by well-trained, and experienced operators they can be correctly identified and classified. Conclusion: Appropriate training of urine laboratory professionals in spheroplast detection and association with UTI, together with timely communication with the microbiologist and caring clinician, will provide prompt targeted treatment.

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