4.6 Editorial Material

Targeting Iron Deficiency in Heart Failure Existing Evidence and Future Expectations

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Randomized Placebo-Controlled Trial of Ferric Carboxymaltose in Heart Failure With Iron Deficiency Rationale and Design

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Summary: Iron deficiency is common in patients with heart failure and is associated with poor prognosis. The HEART-FID trial aims to evaluate the efficacy and safety of ferric carboxymaltose compared to placebo in treating symptomatic heart failure with reduced ejection fraction and iron deficiency. The trial involves a large number of patients from international centers.

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Iron deficiency impairs contractility of human cardiomyocytes through decreased mitochondrial function

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Myocardial and Systemic Iron Depletion in Heart Failure Implications for Anemia Accompanying Heart Failure

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Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency.

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