期刊
CHINESE JOURNAL OF CHEMISTRY
卷 39, 期 8, 页码 2220-2226出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cjoc.202100194
关键词
Photocatalysis; Sulfonated dibenzazepines; Radical reactions; Ugi reaction; Annulation
资金
- National Natural Science Foundation of China [21901027]
- Science and Technology Research Program of Chongqing Municipal Education Commission [KJQN201901345, KJQN201901346]
- Chongqing Natural Science Foundation Postdoctoral Science Foundation Project [cstc2019jcyj-bshX0053]
- Scientific Research Foundation of the Chongqing University of Arts and Sciences [R2019FXY11]
A new method for accessing sulfonated dibenzazepines via visible-light photoredox catalysis is described, utilizing sulfonyl chlorides to form sulfonyl radicals for alkyne addition and radical cyclization reactions. Additionally, an Ugi-type multicomponent reaction can be used for rapid substrate synthesis, simplifying the synthetic steps of highly functionalized sulfonylated dibenzazepines.
Main observation and conclusion A new method to access sulfonated dibenz[b,e]azepines via visible-light photoredox catalysis is described. Employing inexpensive and commercially available sulfonyl chlorides to form the sulfonyl radicals enables the alkyne addition reaction followed by a 7-membered radical cyclization step to furnish sulfonated dibenzazepines. In addition, an Ugi-type multicomponent reaction (MCR) for the synthesis of o-aminophenylacetylene derivatives can also be used as a rapid substrate synthesis method for the cascade radical cyclization protocol to obtain a series of highly functionalized sulfonylated dibenzazepines, which undoubtedly greatly simplifies the synthetic steps of the dibenzazepine compounds that are important core structures in pharmaceuticals.
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