期刊
CHINESE CHEMICAL LETTERS
卷 32, 期 10, 页码 3061-3065出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2021.03.075
关键词
Gastric ulcer; NIR-II bioimaging; Cyclodextrin metal-organic frameworks; Real time; Diagnose
资金
- National Key R&D Program of China [2020YFA0908800]
- National Nature Science Foundation of China [81773674]
- Shenzhen Science and Technology Research Grant [JCYJ20190808152019182]
- Hubei Province Scientific and Technical Innovation Key Project [2020BAB058]
- Applied Basic Research Program of Wuhan Municipal Bureau of Science and Technology [2019020701011429]
- Local Development Funds of Science and Technology Department of Tibet [XZ202001YD0028C]
- Tibet Autonomous Region Science and Technology Plan Project Key Project [XZ201901-GB-11]
- Natural Science Foundation of Hubei [2019CFB679]
- Health Commission of Hubei Province Scientific Research Project [WJ2021Q031]
- Fundamental Research Funds for the Central Universities [ZNJC201931]
The novel CD-MOF NIR-II fluorophore GPs-CH1055 shows strong retention effect and bright NIR-II signals at gastric ulcer sites in vivo, offering great potential for real-time imaging and diagnosis of gastric ulcers.
Gastric ulcers are one of the most common stomach diseases that often accompanied by inflammation, congestion, edema, scar tissue formation, and pyloric obstruction. Fiberoptic endoscopy and X-ray analysis of the upper GI tract have become the diagnostic procedure of choice for patients. However, conventional diagnosis technology is either invasive or radioactive. Herein, a novel CD-MOF NIR-II fluorophore (GPs-CH1055) was developed. The relative fluorophore intensity was largely consistent at various media and pH buffers, and it can swell into gel particles in solvents and be completely expelled from the gastrointestinal tract without being assimilated. GPs-CH1055 has been further evaluated in vivo, and exhibited strong retention effect on the gastric ulcer sites, bright NIR-II signals with high spatial and temporal resolution. Therefore, GPs-CH1055 shows great promise for realizing real-time gastric ulcer imaging and diagnosis. (c) 2021 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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