期刊
CHINESE CHEMICAL LETTERS
卷 32, 期 11, 页码 3487-3490出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2021.04.036
关键词
Gadolinium boride; Nanomedicine; Photothermal therapy; Fluorescence imaging; Theranostics
资金
- National Natural Science Foundation of China [51872188]
- Shenzhen Basic Research Program [JCYJ20170302151858466, JCYJ20170818093808351]
- Special Funds for the Development of Strategic Emerging Industries in Shenzhen [20180309154519685]
- SZU Top Ranking Project [8600 0000210]
- Hubei Key Laboratory of Plasma Chemistry and Advanced Materials for the Open Fund [2020KF02]
This study demonstrated a promising multifunctional theranostic nanoplatform for cancer treatment by synthesizing gadolinium boride nanoparticles, showing potential for fluorescence imaging and photothermal therapy in cancer treatment.
The development of multifunctional theranostic nano-agents is an important resolution for personalized treatment of cancer. In this work, we synthesized a new kind of gadolinium boride nanoparticles (GBN) by a microwave-assisted chemical etching method, and discovered their optical characteristics including fluorescence imaging and near-infrared (NIR) photothermal conversion capability. Bright greenishyellow fluorescence enabled for intracellular localization, while effective NIR-photothermal conversion supported photothermal therapy (PTT). In vitro and in vivo results indicated that GBN exhibited a superior antitumor performance and high biocompatibility. This study demonstrated a promising multifunctional theranostic nanoplatform for cancer treatment. (C) 2021 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
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