Animal Hosts and Experimental Models of SARS-CoV-2 Infection

Viruses arise through cross-species transmission and can cause potentially fatal diseases in humans. This is the case of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which recently appeared in Wuhan, China, and rapidly spread worldwide, causing the outbreak of coronavirus disease 2019 (COVID-19) and posing a global health emergency. Sequence analysis and epidemiological investigations suggest that the most likely original source of SARS-CoV-2 is a spillover from an animal reservoir, probably bats, that infected humans either directly or through intermediate animal hosts. The role of animals as reservoirs and natural hosts in SARS-CoV-2 has to be explored, and animal models for COVID-19 are needed as well to be evaluated for countermeasures against SARS-CoV-2 infection. Experimental cells, tissues, and animal models that are currently being used and developed in COVID-19 research will be presented.

Automated summary

Cross-species transmission of viruses can lead to serious diseases, such as COVID-19. The virus likely originated from an animal reservoir, possibly bats, infecting humans directly or through intermediate hosts. Research should focus on understanding the role of animals in the transmission and developing strategies to combat SARS-CoV-2 infections.