期刊
CHEMOSPHERE
卷 271, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2021.129735
关键词
Heavy metals; Hepatotoxicity; Cadmium; Mercury; Arsenic; Nickel; Chromium; Lead
资金
- VIT SEED GRANT
- ICMR-National Task Force Project [5/7/482/2010-RBMHCH]
Exposure to heavy metals beyond permissible limits poses a serious threat to human health, causing hepatotoxicity, cellular damage, and inflammatory responses.
Heavy metals pose a serious threat if they go beyond permissible limits in our bodies. Much heavy metal's viz. Lead, Chromium, Arsenic, Mercury, Nickel, and Cadmium pose a serious threat when they go beyond permissible limits and cause hepatotoxicity. They cause the generation of ROS which in turn causes numerous injuries and undesirable changes in the liver. Epidemiological studies have shown an increase in the levels of such heavy metals in the environment posing a serious threat to human health. Epigenetic alterations have been seen in the event of exposure to such heavy metals. Apoptosis, caspase activation as well as ultrastructural changes in the hepatocytes have also been seen due to heavy metals. Inflammation involving TNF-alpha, pro-inflammatory cytokines, MAPK, ERK pathways have been seen in the event of heavy metal hepatotoxicity. All these have shown that these heavy metals pose a serious threat to human health in particular and the environment as a whole. (C) 2021 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据