期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 27, 期 40, 页码 10226-10246出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202100756
关键词
asymmetric catalysis; Bronsted base catalysis; C-H functionalization; dienolates; regioselectivity
资金
- University of the Basque Country UPV/EHU [UFI QOSYC 11/22]
- Basque Government [IT-1236-19]
- Ministerio de Ciencia e Innovation [PID2019109633GB C21]
The catalyst-controlled functionalization of unmodified carbonyl compounds is an important operation in organic synthesis, especially when high levels of site- and stereo-selectivity can be achieved. Recent contributions in this field have shown that some subsets of enolizable substrates can now be functionalized through various types of activation mechanisms.
Catalyst-controlled functionalization of unmodified carbonyl compounds is a relevant operation in organic synthesis, especially when high levels of site- and stereo-selectivity can be attained. This objective is now within reach for some subsets of enolizable substrates using various types of activation mechanisms. Recent contributions to this area include enantioselective transformations that proceed via transiently generated noncovalent di(tri)enolate-catalyst coordination species. While relatively easier to form than simple enolate congeners, di(tri)enolates are ambifunctional in nature and so control of the reaction regioselectivity becomes an issue. This Minireview discusses in some detail this and other problems, and how noncovalent activation approaches based on metallic and metal free catalysts have been developed to advance the field.
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