期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 27, 期 22, 页码 6783-6794出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202100375
关键词
bioorganometallic chemistry; cellular imaging; iridium; luminescence lifetime; rhodium
资金
- Access to confocal microscopes in the Department of Anatomy and Embryology at the Ruhr-Universitt Bochum
The synthesis of luminescent Rh-I and Ir-I [M(COD)(NHC)I] complexes with 1,8-naphthalimide-based emitting ligands has been reported, and the complexes were found to predominantly accumulate in the endoplasmic reticulum, providing new insights into the cellular localization of such Ir-I(NHC) complexes.
Complexes of Rh-I and Ir-I of the [M(COD)(NHC)X] type (where M=Rh or Ir, COD=1,5-cyclooctadiene, NHC=N-heterocyclic carbene, and X=halide) have recently shown promising cytotoxic activities against several cancer cell lines. Initial mechanism of action studies provided some knowledge about their interaction with DNA and proteins. However, information about their cellular localization remains scarce owing to luminescence quenching within this complex type. Herein, the synthesis of two rare examples of luminescent Rh-I and Ir-I [M(COD)(NHC)I] complexes with 1,8-naphthalimide-based emitting ligands is reported. All new complexes are comprehensively characterized, including with single-crystal X-ray structures. Steric crowding in one derivative leads to two distinct rotamers in solution, which apparently can be distinguished both by pronounced NMR shifts and by their respective spectral and temporal emission signatures. When the photophysical properties of these new complexes are exploited for cellular imaging in HT-29 and PT-45 cancer cell lines, it is demonstrated that the complexes accumulate predominantly in the endoplasmic reticulum, which is an entirely new finding and provides the first insight into the cellular localization of such Ir-I(NHC) complexes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据