期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 27, 期 29, 页码 7915-7922出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202100655
关键词
aromatic aldehydes; amides; esters; hydroxamic acids; green chemistry; photochemistry
资金
- Hellenic Foundation for Research and Innovation (HFRI)
- State Scholarships Foundation (IKY)
- European Union (European Social Fund-ESF) through the Operational Programme Human Resources Development, Education and Lifelong Learning [MIS-5000432]
- COST Action C H Activation in Organic Synthesis (CHAOS) [CA15106]
- [655]
A cost-effective and straightforward photochemical method has been developed for the activation of aromatic aldehydes, leading to the conversion into various products including a drug for depression and social anxiety. Detailed mechanistic studies have been conducted to determine a plausible mechanism for the reaction.
A cheap, facile and metal-free photochemical protocol for the activation of aromatic aldehydes has been developed. Utilizing thioxanthen-9-one as the photocatalyst and cheap household lamps as the light source, a variety of aromatic aldehydes have been activated and subsequently converted in a one-pot reaction into amides, hydroxamic acids and esters in good to high yields. The applicability of this method was highlighted in the synthesis of Moclobemide, a drug against depression and social anxiety. Extended and detailed mechanistic studies have been conducted, in order to determine a plausible mechanism for the reaction.
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