期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 27, 期 36, 页码 9276-9280出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202101080
关键词
alkenyl halides; Heck reactions; palladium; relay; unsaturated alcohols
资金
- Firmenich SA Funding Source: Medline
Unactivated alkenyl iodides and bromides underwent a palladium-catalyzed relay-Heck cross-coupling with alkenols to afford unsaturated aldehydes and ketones in moderate to good yields, while alkenyl triflates were not suitable partners for this reaction. This method allowed the preparation of open-chain analogues of the musk odorant Vulcanolide, some of which retained key olfactory properties of the parent molecule.
Unactivated alkenyl iodides and bromides underwent an unprecedented palladium-catalyzed relay-Heck cross-coupling with a whole range of alkenols of different chain lengths linking the alkene and the alcohol, affording unsaturated aldehydes and ketones in moderate to good yields. In contrast, alkenyl triflates were not suitable partners for this reaction. This method allowed the preparation of open-chain analogues of the musk odorant Vulcanolide, several of which retained key olfactory properties of the parent molecule.
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