期刊
EPL
卷 114, 期 3, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1209/0295-5075/114/30001
关键词
-
资金
- National Natural Science Foundation of China [81571770, 61527815, 61201278, 81371636, 81401484, 81330032]
- Slovenian Research Agency [P5-0027, J1-7009]
Fast-spiking (FS) interneurons in the brain are self-innervated by powerful inhibitory GABAergic autaptic connections. By computational modelling, we investigate how autaptic inhibition regulates the firing response of such interneurons. Our results indicate that autaptic inhibition both boosts the current threshold for action potential generation and modulates the input-output gain of FS interneurons. The autaptic transmission delay is identified as a key parameter that controls the firing patterns and determines multistability regions of FS interneurons. Furthermore, we observe that neuronal noise influences the firing regulation of FS interneurons by autaptic inhibition and extends their dynamic range for encoding inputs. Importantly, autaptic inhibition modulates noise-induced irregular firing of FS interneurons, such that coherent firing appears at an optimal autaptic inhibition level. Our results reveal the functional roles of autaptic inhibition in taming the firing dynamics of FS interneurons. Copyright (C) EPLA, 2016
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