期刊
CHEMICAL ENGINEERING JOURNAL
卷 420, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2021.130302
关键词
Wound healing; Hydrogels; Self-healing; Angiogenesis; Antibacterial activity
资金
- National Key Research and Development Program of China [2017YFB0702600, 2017YFB0702603]
- Sichuan Science and Technology Program [2020YFS0038, 2019JDTD0008]
A self-healing hydrogel with angiogenic and antibacterial properties was developed for skin wound repair in this study. The hydrogel exhibited good mechanical properties and biocompatibility, accelerating wound healing and reducing scar formation.
Skin wound healing occurs via a series of orchestrated cellular and molecular events in a highly ordered manner, in which insufficient angiogenesis and infection at the wound site always retard the healing process. Hence, hydrogel wound dressing with multifunctional properties, including angiogenic and antibacterial properties, would be highly desired in practical application. In the present study, we developed a series of self-healing hydrogels based on L-arginine conjugated chitosan (CA), benzaldehyde group functionalized poly (ethylene glycol) (CHO-PEG-CHO), and polydopamine nanoparticles (pDA-NPs), named as CA-pDA, as an angiogenic and antibacterial dressing for wound repair. The CA-pDA hydrogels showed porous architecture, good adhesiveness and self-healing properties, as well as good biocompatibility. Particularly, the incorporation of pDA-NPs could enhance the mechanical property (-1.5-4.5 times) and pore size (-1.2 times) of pure CA hydrogel. The in vitro data demonstrated that CA hydrogel had limited capacities for inducing angiogenesis and inhibiting bacterial colony growth, while the two properties of the hydrogel could be enhanced by the incorporation of pDA-NPs. In addition, CA-pDA hydrogels, especially CA-pDA2, could accelerate wound healing with reduced scar formation in a large full-thickness skin defect (2 x 2 cm2) of a rat model. After 14 days post-surgery, the wound healing ratio in CA-pDA2 (-99%) was significantly higher than that in the control group (-79%). Collectively, the fabricated CA-pDA2 with enhanced angiogenic and antibacterial activities could have good potential for clinical wound dressing application.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据