期刊
CHEMICAL ENGINEERING JOURNAL
卷 426, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2021.130299
关键词
Bioactive glass; nano-HCA@BG; Dynamic immersion; Porous structure; Wound healing
资金
- National Natural Science Foundation of China [U1732155, 3190110313, U1632274]
- Ministry of Science and Technology of China [2016YFA0400901]
- Doctor Research Fund of Henan University of Technology [2019BS019]
- HighMagnetic Field Laboratory of Anhui Province
A novel approach was proposed to produce nano-HCA@BG for soft tissue repair, which improved biocompatibility through a porous structure and surface-coated amorphous HCA layer. The HCA-coated nanoporous architecture significantly promoted cell growth and proliferation, benefiting wound healing in rodent skin defects.
Borate bioactive glass (BBG) stimulates angiogenesis and promotes cell growth. However, controlling the degradation rate of BBG and maintaining the critical concentration of bioactive ions suitable for cell promotion and differentiation remain great challenges in soft tissue repair. In this study, a novel approach was proposed to produce nanosized CO32- -containing hydroxyapatite (HCA)-coated BBG (nano-HCA@BG). Unlike the previously reported hard-to-degrade hydroxyapatite (HA) coating after static soaking treatment of BBG, the nano-HCA@BG, obtained by dynamically immersing the BBG powder in a flowing buffer, had a porous structure and was surfacecoated with a layer of amorphous HCA, which improved the biocompatibility and retained the biodegradability of BBG. The effects of nano-HCA@BG were evaluated and compared with those of powdered BBG at the cellular and animal levels. The formation of the HCA-coated nanoporous architecture significantly improves biocompatibility, promotes cell growth and proliferation, and is beneficial for wound healing in rodent skin defects.
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