期刊
CHEMICAL ENGINEERING JOURNAL
卷 411, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2020.128364
关键词
Tumor microenvironment; Catalytic nanomedicine; Photothermal therapy; Chemodynamic therapy; Nanomedicine
资金
- Cyrus Tang Foundation
- National Natural Science Foundation of China [82072782]
- Shanghai Hospital Development Center [SHDC12018X22, SHDC2020CR2009A, SHDC12020125]
- Science Foundation of Shanghai [19411966800]
- Children's National Medical Center [EK1125180112, EK112520180301]
Chemodynamic therapy using Fenton reactions to produce cytotoxic hydroxyl radicals has shown limited efficacy due to low endogenous H2O2 levels. This study developed a cascade catalytically reactive nanosystem using glucose oxidase to generate H2O2 for Fenton reactions, combined with photothermal therapy in the NIR-II window, resulting in enhanced anticancer effects in both epithelial and embryonal tumors.
Chemodynamic therapy, which produces cytotoxic hydroxyl radicals through intratumoral Fenton reactions, has been extensively explored in nanomedicine for cancer treatment. However, the limited endogenous hydrogen peroxide (H2O2) levels, which serve as the reactant, weakens the anticancer effect of the Fenton reaction. In this work, a cascade catalytically reactive nanosystem has been constructed for the treatment of epithelial and embryonal tumors with high synergetic efficacy through the integration of natural glucose oxidase (GOD) and polyethylene glycol (PEG) onto the surface of Fe3S4 nanoplates (abbreviated as Fe3S4-PEG-GOD NPs). The GOD component consumes glucose in tumor and produces a large amount of H2O2, which provides rich substrates for the Fenton reaction catalyzed by the Fe catalytic center of the nanoplates. The intriguing photothermal conversion efficiency (45%) of the constructed composite nanocatalysts in the second near infrared (NIR-II) biowindow allows for photothermal treatment to substantially strengthen and synergize the anticancer effects of nanocatalysts both in vitro and in vivo. This synergy occurs through generation of a hyperthermic effect necessary for promoting the sequential catalytic reaction. The synergistic anticancer effect has been verified in both epithelial and embryonal tumor mouse models, and provides justification for the biomedical use of multifunctional nanocatalysts for versatile tumor nanotherapeutics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据