期刊
CHEMICAL ENGINEERING JOURNAL
卷 410, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2020.127616
关键词
Biodegradable metals; Magnesium alloy; Sodium; Osteogenesis; Calvarial defect
资金
- National Natural Science Foundation of China, China [51871004, 31700819, 81802152]
- NSFC/RGC Joint Research Scheme [5161101031]
- Young Elite Scientists Sponsorship Program by CAST [YESS] [2018QNRC001]
- Fundamental Research Funds for the Central Universities, China [06500098]
- Hong Kong RGC Theme-based Research Scheme [T13-402/17-N]
- RGC Collaborative Research Fund [C4026-17WF]
The study demonstrated the incorporation of essential element sodium into a biodegradable magnesium alloy through Sn-Na master alloying technique, leading to improved hardness and corrosion resistance. The co-release of magnesium and sodium ions promoted bone regeneration by increasing the expression of specific genes and growth factors related to osteogenesis and angiogenesis. This innovative approach using master alloy showed promise in fabricating biodegradable magnesium alloys with enhanced biological functions.
Biodegradable metals have great attraction to become orthopaedic implants. Here, we demonstrated a biodegradable magnesium alloy incorporated with essential element sodium through Sn-Na master alloying technique. The designed MgSnZnNa alloy presented better hardness and corrosion resistance due to the uniform distribution of Na in Mg2Sn second phase and solid soluble Zn in Mg matrix. The co-release of Mg and Na ions resulted in advanced upregulation of osterix and osteocalcin expression in adipose derived stem cells in vitro. It significantly promoted the rat calvarial defect bone regeneration through osteogenesis and angiogenesis, attributed to the co release of Na and Mg ions, by increasing the expression of calcitonin gene-related peptide, osteocalcin as well as vascular endothelial growth factor. The current study provided an innovative approach by using master alloy to incorporate essential elements (such as Na or K) for fabricating biodegradable Mg alloys with reduced galvanic corrosion and enhanced biological functions.
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