期刊
CHEMICAL ENGINEERING JOURNAL
卷 409, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2020.128224
关键词
Multifunctional injectable hydrogel system; CuS nanoparticles; Antibacterial treatment; Skin-tumor therapy; Wound healing acceleration
资金
- National Natural Science Foundation of China [51973130, 51673129]
This study developed a CuS nanoparticle complex hydrogel system with multiple functions, including excellent self-healing ability, photothermal/photodynamic performance, and biocompatibility, for accelerating wound healing.
It is of significant importance to develop an injectable self-healing hydrogel system that can simultaneously deal with antibacterial treatment, tumor therapy and wound healing acceleration for biomedical fields. Herein, a system of CuS nanoparticle complex (CuS NC) hydrogels with multiple functions is firstly developed through incorporating polyethylene glycol (PEG)-functionalized CuS nanoparticles (CuS NPs) with surface amino groups into a 3D network of oxidized dextran (ODex) and PEG with amino end groups. The in situ formed CuS NC hydmgels display not only excellent self-healing and injectable abilities, but also good biocompatibility for biomedical application. The introduction of CuS NPs endows the hydmgels with outstanding photothermal/photodynamic performance under near-infrared laser irradiation, creating the capability to fully kill S.aureus and E.coli bacteria, and to inhibit tumor growth in a subcutaneous skin-tumor model. The CuS NC hydmgels maintain sustained release of Cu2+ and moist microenvironment, and thus effectively accelerate wound healing in vivo. This work illustrates a facile strategy to prepare injectable, multifunctional nanoparticle hybrid hydrogels which can be used severally or simultaneously for bacterial infection treating, skin wound healing and skin-tumor therapy.
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