期刊
CHEMICAL ENGINEERING JOURNAL
卷 424, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2021.130148
关键词
Bioactive multifunctional scaffold; Multimodal Therapy; Infected-wound healing; MXene@CeO2 nanocomposites
资金
- State Key Program of National Natural Science of China [51433008]
- Fundamental Research Funds for the Central Universities [310201911fz051]
- National Natural Science Foundation of China [51673156]
- Natural Science Foundation of Shaanxi Province, China [2020JQ160]
This study successfully developed multifunctional MXene@CeO2 nanocomposites for a hydrogel scaffold with various properties for treating MDR-infected skin, including self-healing, anti-inflammatory, antibacterial, antioxidative, conductive, tissue-adhesive, and hemostatic capabilities. The scaffold showed efficacy in promoting cell migration and proliferation, accelerating wound healing, and addressing multidrug resistant infections.
Overcoming multidrug-resistant (MDR) bacterial infection and simultaneously enhancing wound healing/skin reconstruction are still critical challenges for both clinic practice and fundamental research. The single modal therapy strategy is usually inefficient. Herein, for the first time, multifunctional MXene@CeO2 nanocomposites were prepared by combining the 2D antibacterial conductive Ti3C2Tx MXenes and antioxidant CeO2 and applied in developing multifunctional hydrogel scaffold (FOM) for MDR infection-impaired skin multimodal therapy. FOM scaffold was fabricated by incorporating MXene@CeO2 nanocomposites in a dynamic Schiff-based chemical crosslinked hydrogel of polyethylenimine grafted Pluronic F127 (F127-PEI) and oxidized sodium alginate (OSA). FOM scaffold possessed multifunctional properties including injectable self-healing behavior, efficient antiinflammatory, antibacterial, and antioxidative abilities, conductive bioactivities, tissue-adhesive ability and fast hemostatic capacity. FOM scaffold could promote fibroblasts migration and cell proliferation with electrical stimulation. Additionally, FOM scaffold demonstrated the significant anti-inflammatory and multidrug resistant infection therapy, meanwhile promoting fibroblasts proliferation, granulation tissue formation, collagen deposition, re-epithelialization to accelerate MDR-infected wound healing. This work firstly demonstrated the important role of multifunctional MXene@CeO2 nanocomposites in infected-wound healing/skin reconstruction. This study provided an efficient multimodal therapy on MDR infection-impaired skin via the optimization of the structure and multifunctional properties of biomaterials.
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