Recent Advances in Late-Stage Construction of Stapled Peptides via C-H Activation

Stapled peptides have been widely applied in many fields, including pharmaceutical chemistry, diagnostic reagents, and materials science. However, most traditional stapled peptide preparation methods rely on prefunctionalizations, which limit the diversity of stapled peptides. Recently, the emergence of late-stage transition metal-catalyzed C-H activation in amino acids and peptides has attracted wide interest due to its robustness and applicability for peptide stapling. In this review, we summarize the methods for late-stage construction of stapled peptides via transition metal-catalyzed C-H activation.

Automated summary

The late-stage transition metal-catalyzed C-H activation method provides a way to increase the diversity of stapled peptides, attracting wide interest due to its robustness and applicability for peptide stapling. This review summarizes the methods for late-stage construction of stapled peptides via transition metal-catalyzed C-H activation.