4.6 Article

Low-Intensity Pulsed Ultrasound Stimulation Inhibits Cortical Spreading Depression

期刊

CEREBRAL CORTEX
卷 31, 期 8, 页码 3872-3880

出版社

OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhab055

关键词

behavioral test; cortical spreading depression; intrinsic signal optical imaging; pulsed ultrasound stimulation; western blot

资金

  1. National Natural Science Foundation of China [61827811, 62050068]
  2. Key Project of the Natural Science Foundation of Hebei Province [F2018203256]

向作者/读者索取更多资源

The study demonstrates that low-intensity pulsed ultrasound stimulation (PUS) significantly inhibits cortical spreading depression (CSD) in rats by improving motor activity, reducing CSD propagation speed, and increasing levels of brain-derived neurotrophic factor protein in brain tissue. These findings suggest that PUS has the potential to be a treatment for brain disorders associated with CSD.
Cortical spreading depression (CSD), which is closely correlated with migraine aura, cerebral ischemia, seizure, and brain injury, is a spreading wave of neuronal and glial depolarization. The purpose of this study is to investigate whether low-intensity pulsed ultrasound stimulation (PUS) inhibits CSD by modulating neural activity and hemodynamics. Behavioral test, intrinsic signal optical imaging and western blot analysis were used for evaluating the inhibition effect of PUS on CSD in rat. We found that: 1) 30 min of PUS can significantly improve motor activity of rat with CSD. 2) Both 30 s and 30 min of PUS can significantly reduce count and propagation speed of CSD in rat and the inhibitory effect was enhanced with increase of ultrasound intensity. 3) 30 min of PUS significantly enhanced levels of brain-derived neurotrophic factor protein in brain tissue with CSD. These results suggest that PUS has the potential to treat brain disorders associated with CSD.

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