4.6 Article

Association between Quantitative MR Markers of Cortical Evolving Organization and Gene Expression during Human Prenatal Brain Development

期刊

CEREBRAL CORTEX
卷 31, 期 8, 页码 3610-3621

出版社

OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhab035

关键词

cortical evolving organization; cortical thickness; fetus; fetal brain; gene expression; subplate

资金

  1. Ralph Schlaeger Foundation in Neuroradiology
  2. National Institute of Neurological Disorders and Stroke of the National Institutes of Health [K23NS101120]
  3. American Academy of Neurology Clinical Research Training Fellowship
  4. NARSAD Young Investigator Award from the Brain and Behavior Foundation
  5. National Institutes of Health [R01EB018988, R01NS106030, R01EB013248, R01MH092535, R01MH092535-S1, U54HD086984]
  6. Technological Innovations in Neuroscience Award from the McKnight Foundation
  7. Fetal Health Foundation

向作者/读者索取更多资源

This study reveals an association between structural changes in the cerebral cortex and gene expression levels, particularly highlighting the relationship between the FLNA gene and cortical evolving organization. The findings suggest the need for further research to identify early MRI biomarkers of gene expression in abnormal cortical development.
The relationship between structural changes of the cerebral cortex revealed by Magnetic Resonance Imaging (MRI) and gene expression in the human fetal brain has not been explored. In this study, we aimed to test the hypothesis that relative regional thickness (a measure of cortical evolving organization) of fetal cortical compartments (cortical plate [CP] and subplate [SP]) is associated with expression levels of genes with known cortical phenotype. Mean regional SP/CP thickness ratios across age measured on in utero MRI of 25 healthy fetuses (20-33 gestational weeks [GWs]) were correlated with publicly available regional gene expression levels (23-24 GW fetuses). Larger SP/CP thickness ratios (more pronounced cortical evolving organization) was found in perisylvian regions. Furthermore, we found a significant association between SP/CP thickness ratio and expression levels of the FLNA gene (mutated in periventricular heterotopia, congenital heart disease, and vascular malformations). Further work is needed to identify early MRI biomarkers of gene expression that lead to abnormal cortical development.

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