4.6 Article

Distribution of the Noradrenaline Innervation and Adrenoceptors in the Macaque Monkey Thalamus

期刊

CEREBRAL CORTEX
卷 31, 期 9, 页码 4115-4139

出版社

OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhab073

关键词

dopamine-beta-hydroxylase; nonhuman primates; noradrenergic receptors; norepinephrine; norepinephrine transporter

资金

  1. Chair in Neuroscience UAM-Fundacion Tatiana Perez de Guzman el Bueno
  2. German Federal Ministry of Education and Research [01GQ1902]
  3. European Union's Horizon 2020 Research and Innovation Programme [785907, 945539]
  4. Boehringer Ingelheim Fonds
  5. Universidad Autonoma de Madrid

向作者/读者索取更多资源

The study reveals that Noradrenaline (NA) plays important roles in modulating thalamic functions related to consciousness, emotion, cognition, and executive functions, with different levels of innervation and receptor densities across thalamic nuclei. The findings suggest a close relationship between NA axonal densities and Alpha adrenoceptor densities in the thalamus.
Noradrenaline (NA) in the thalamus has important roles in physiological, pharmacological, and pathological neuromodulation. In this work, a complete characterization of NA axons and Alpha adrenoceptors distributions is provided. NA axons, revealed by immunohistochemistry against the synthesizing enzyme and the NA transporter, are present in all thalamic nuclei. The most densely innervated ones are the midline nuclei, intralaminar nuclei (paracentral and parafascicular), and the medial sector of the mediodorsal nucleus (MDm). The ventral motor nuclei and most somatosensory relay nuclei receive a moderate NA innervation. The pulvinar complex receives a heterogeneous innervation. The lateral geniculate nucleus (GL) has the lowest NA innervation. Alpha adrenoceptors were analyzed by in vitro quantitative autoradiography. Alpha-1 receptor densities are higher than Alpha-2 densities. Overall, axonal densities and Alpha adrenoceptor densities coincide; although some mismatches were identified. The nuclei with the highest Alpha-1 values are MDm, the parvocellular part of the ventral posterior medial nucleus, medial pulvinar, and midline nuclei. The nucleus with the lowest Alpha-1 receptor density is GL. Alpha-2 receptor densities are highest in the lateral dorsal, centromedian, medial and inferior pulvinar, and midline nuclei. These results suggest a role for NA in modulating thalamic involvement in consciousness, limbic, cognitive, and executive functions.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据