期刊
CERAMICS INTERNATIONAL
卷 47, 期 15, 页码 21045-21050出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceramint.2021.04.106
关键词
Biosynthesis; Barium carbonate nanoparticles; BaCO3; Cancer therapy; Glioblastoma cell line; MTT assay; Green chemistry
资金
- Taif University Researchers Supporting Program, Taif University, Saudi Arabian, Bam [TURSP-2020/269]
- Kerman University of Medical Sciences
The biosynthesis of barium carbonate nanoparticles using plant-mediated synthesis shows promising potential for biomedical applications, especially in cancer therapy, due to their useful medicinal potentials and suitable biocompatibility. The nanostructures were characterized using X-ray diffraction, scanning electron microscopy, and transmission electron microscope, and their toxicity on U87 brain cancer cells was evaluated, showing the prepared nanostructures can be employed for biomedical applications.
In recent years, nanostructures and nanoarchitectures have attracted much attention in the development of biomedicine and nanomedicine. The plant-mediated synthesis of barium carbonate nanoparticles (BACN) has been performed using barium chloride and aqueous extract of natural sweetener (Stevia). In this study, the biosynthesis of BACN has been selected due to the useful medicinal potentials and suitable obtained biocompatibility of produced nanoparticles as well as its simplicity, lesser production steps, and cost-effectiveness. Barium carbonate nanostructures were characterized by X-ray diffraction, scanning electron microscopy, and transmission electron microscope. The toxicity of BACN on U87 brain cancer cells was evaluated based on MTT assay. According to the results, the prepared nanostructures can be employed for biomedical applications, especially cancer therapy.
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