期刊
CELLULAR AND MOLECULAR NEUROBIOLOGY
卷 42, 期 7, 页码 2031-2053出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10571-021-01091-6
关键词
miR-124; Therapeutic target; Central nervous system injuries; Neurodegenerative diseases; Delivery methods
资金
- National Natural Science Foundation of China [81870974]
- Fundamental Research Funds for the Central Universities
Studies have shown that microRNA-124 is closely related to the occurrence and development of pathology within the central nervous system. Understanding the molecular regulatory functions and effective delivery methods of miR-124 may hold potential for therapeutic targets in treating central nervous system injuries or diseases.
Central nervous system injuries and diseases, such as ischemic stroke, spinal cord injury, neurodegenerative diseases, glioblastoma, multiple sclerosis, and the resulting neuroinflammation often lead to death or long-term disability. MicroRNAs are small, non-coding, single-stranded RNAs that regulate posttranscriptional gene expression in both physiological and pathological cellular processes, including central nervous system injuries and disorders. Studies on miR-124, one of the most abundant microRNAs in the central nervous system, have shown that its dysregulation is related to the occurrence and development of pathology within the central nervous system. Herein, we review the molecular regulatory functions, underlying mechanisms, and effective delivery methods of miR-124 in the central nervous system, where it is involved in pathological conditions. The review also provides novel insights into the therapeutic target potential of miR-124 in the treatment of human central nervous system injuries or diseases.
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