期刊
CELLULAR AND MOLECULAR NEUROBIOLOGY
卷 42, 期 7, 页码 2219-2234出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10571-021-01096-1
关键词
Glioma; Proliferation; Invasion; Angiogenesis; GAM; Dichotomy
资金
- Council of Scientific and Industrial Research (CSIR), Government of India [37(1587)/13/EMR-II]
The study finds that in glioma, proliferation is high in lower grades (LG) supported by VEGF-dependent angiogenesis maintenance, while this angiogenesis decrease is unlikely in higher grades (HG). On the other hand, invasion associated with MMP 2 and 9 is increased in HG, along with a dominant presence of CD204(+) M2 polarized macrophages and a general increase in global DNMT1-associated methylation.
Glial dysfunction outraging CNS plasticity and integrity results in one of the most dangerous cancers, namely glioma, featuring little median survival period and high recurrence. The hallmark properties of proliferation, invasion and angiogenesis with the infiltrated macrophages in glioma are expected to be tightly coupled or cross-linked, but not properly related so far. The present study is aimed to find a relationship between this featured quadrangle from lower to higher grades (HG) of post-operative glioma tissues and their invading subsets. Elevated Ki67-associated proliferation in lower grades (LG) was supported with VEGF dependent angiogenic maintenance which found a decrease unlikely in HG. In contrast, MMP 2 and 9-associated invasions augmented high in HG with the dominant presence of CD204(+) M2 polarized macrophages and a general increase in global DNMT1-associated methylation. Marked differences found in ECM invading cellular subsets of HG showing high proliferative capacity indicating rationally for recurrence, contrasting the nature of gross tumor tissue of the same grade. Thus in LG, the neoplastic lesion is more inclined to its growth while in higher grade more disposed towards tissue wreckage in support with cellular environmental milieu whereas the cellular variants and subsets of invaded cells showed different trends. Therefore, some operational dichotomy or coupling among cellular variants in glioma is active in determining its low- to high-grade transition and aggressive progression.
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