期刊
CELLULAR & MOLECULAR IMMUNOLOGY
卷 18, 期 5, 页码 1186-1196出版社
CHIN SOCIETY IMMUNOLOGY
DOI: 10.1038/s41423-021-00673-0
关键词
cGAS; Mita; Sting; mitostress; innate immune response; mitochondrial DNA
类别
资金
- State Key R&D Program of China [2017YFA0505800]
- National Natural Science Foundation of China [31830024, 31922021, 31771555, 31630045, 31801188]
- CAMS Innovation Fund for Medical Sciences [2019-I2M-5-071]
The study identified VRK2 as a key regulator of mtDNA release in response to mitochondrial stress, viral infection, and nonviral factors causing Ca2+ overload. VRK2 plays a crucial role in triggering the cGAS-mediated innate immune response and may serve as a potential therapeutic target for infectious and autoimmune diseases associated with mtDNA release.
Mitochondrial stress (mitostress) triggered by viral infection or mitochondrial dysfunction causes the release of mitochondrial DNA (mtDNA) into the cytosol and activates the cGAS-mediated innate immune response. The regulation of mtDNA release upon mitostress remains uncharacterized. Here, we identified mitochondria-associated vaccinia virus-related kinase 2 (VRK2) as a key regulator of this process. VRK2 deficiency inhibited the induction of antiviral genes and caused earlier and higher mortality in mice after viral infection. Upon viral infection, VRK2 associated with voltage-dependent anion channel 1 (VDAC1) and promoted VDAC1 oligomerization and mtDNA release, leading to the cGAS-mediated innate immune response. VRK2 was also required for mtDNA release and cGAS-mediated innate immunity triggered by nonviral factors that cause Ca2+ overload but was not required for the cytosolic nucleic acid-triggered innate immune response. Thus, VRK2 plays a crucial role in the mtDNA-triggered innate immune response and may be a potential therapeutic target for infectious and autoimmune diseases associated with mtDNA release.
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