期刊
CELLS TISSUES ORGANS
卷 211, 期 2, 页码 110-133出版社
KARGER
DOI: 10.1159/000515289
关键词
Epithelial-mesenchymal plasticity; Epithelial-mesenchymal transition; Mesenchymal; epithelial transition; E; M hybrid; Partial epithelial; mesenchymal plasticity; Computational biology; Molecular modelling; Cancer
资金
- SPARC grant - MHRD, Government of India [SPARC/2018-2019/P303/SL]
- National Breast Cancer Foundation [CG-10-04, CBCNBCF-19-009]
- Cancer Council Victoria [APP1187825]
- Cure Brain Cancer
- Betty Smyth Centenary Fellowship in Bioinformatics
- QUT Postgraduate Research Award scholarship
- Australian Government
- National Breast Cancer Foundation [CBCNBCF-19-009] Funding Source: researchfish
The epithelial-mesenchymal (E/M) hybrid state plays a significant role in cancer progression, facilitated by epithelial mesenchymal plasticity (EMP). Modeling and validation studies have shown the stabilised E/M hybrid states across the spectrum of EMP, along with computational approaches for characterising EMP phenotypes.
The epithelial-mesenchymal (E/M) hybrid state has emerged as an important mediator of elements of cancer progression, facilitated by epithelial mesenchymal plasticity (EMP). We review here evidence for the presence, prognostic significance, and therapeutic potential of the E/M hybrid state in carcinoma. We further assess modelling predictions and validation studies to demonstrate stabilised E/M hybrid states along the spectrum of EMP, as well as computational approaches for characterising and quantifying EMP phenotypes, with particular attention to the emerging realm of single-cell approaches through RNA sequencing and protein-based techniques.
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