期刊
CELLS TISSUES ORGANS
卷 211, 期 2, 页码 222-237出版社
KARGER
DOI: 10.1159/000513039
关键词
Chorioallantoic membrane; Tumor; Cancer; Patient-derived xenograft
资金
- Yushan Scholar Program by the Ministry of Education, Taiwan [NTU-109V0402]
- NTU Core Consortiums [NTUCC-109L893001]
The chick CAM model has been a valuable alternative in oncology research, showing increased xenograft take rates and retention of tumor heterogeneity. Various imaging techniques and data analysis have been widely applied to study tumor metastasis, angiogenesis, and therapeutic response to novel agents.
A variety of in vivo experimental models have been established for the studies of human cancer using both cancer cell lines and patient-derived xenografts (PDXs). In order to meet the aspiration of precision medicine, the in vivomurine models have been widely adopted. However, common constraints such as high cost, long duration of experiments, and low engraftment efficiency remained to be resolved. The chick embryo chorioallantoic membrane (CAM) is an alternative model to overcome some of these limitations. Here, we provide an overview of the applications of the chick CAM model in the study of oncology. The CAM model has shown significant retention of tumor heterogeneity alongside increased xenograft take rates in several PDX studies. Various imaging techniques and data analysis have been applied to study tumor metastasis, angiogenesis, and therapeutic response to novel agents. Lastly, to practically illustrate the feasibility of utilizing the CAM model, we summarize the general protocol used in a case study utilizing an ovarian cancer PDX.
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