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Article Neurosciences

Long-term self-renewing stem cells in the adult mouse hippocampus identified by intravital imaging

Sara Bottes et al.

Summary: Researchers identified long-term self-renewing neural stem cells (NSCs) in the adult mouse hippocampus using intravital imaging and single-cell RNA sequencing. They found that Gli1-targeted NSCs exhibit long-term self-renewal, while Ascl1-targeted NSCs have limited proliferative activity before exhaustion. The study revealed the existence of heterogeneous NSC populations with diverse behavioral properties in contributing to neurogenesis in the adult hippocampus.

NATURE NEUROSCIENCE (2021)

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Article Cell & Tissue Engineering

Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population

Lachlan Harris et al.

Summary: The stabilization of neural stem cell numbers in young adults is a result of coordinated changes in stem cell behavior, with resting cells having a higher activation rate and greater contribution to neurogenesis. This change is associated with a progressive reduction in expression of the pro-activation protein ASCL1 due to increased post-translational degradation, providing insights into hippocampal NSC dynamics and neurogenesis rates in different mammalian species, including humans.

CELL STEM CELL (2021)

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Article Cell & Tissue Engineering

Early stem cell aging in the mature brain

Albina Ibrayeva et al.

Summary: The research highlights the vulnerability and adaptability of hippocampal neural stem cells to cellular aging, as multiple factors disrupt these cells' behavior in the adult brain, including rapid-dividing short-term NSCs and multipotent long-term NSCs maintained for months but pushed out of homeostasis by extended quiescence.

CELL STEM CELL (2021)

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Article Biochemistry & Molecular Biology