4.7 Editorial Material

Neutrophil elastase: Nonsense lost in translation

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Article Cell & Tissue Engineering

Dissecting ELANE neutropenia pathogenicity by human HSC gene editing

Shuquan Rao et al.

Summary: A study used a pooled CRISPR screen to uncover the correlation between ELANE mutations and neutrophil maturation potential, successfully overcoming maturation blockage in patients with congenital neutropenia through gene editing and establishing relevant animal models. Different types of chromosomal variations impact neutrophil maturation, which is crucial for elucidating disease mechanisms and developing universal treatment approaches.

CELL STEM CELL (2021)

Article Oncology

ELANE Mutations in Cyclic and Severe Congenital Neutropenia Genetics and Pathophysiology

Marshall S. Horwitz et al.

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2013)