Developments in pluripotency: a new formative state

Article Cell & Tissue Engineering

Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification

Leqian Yu et al.

Summary: The study successfully derived XPSCs from mice, horses, and humans by modulating various growth factor pathways, which have the capability to induce PGC-like cells in vitro and form chimeras in vivo. XPSCs represent a pluripotency state between naive and primed pluripotency, and hold features characteristic of formative pluripotency.

CELL STEM CELL (2021)

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Article Cell & Tissue Engineering

Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency

Masaki Kinoshita et al.

Summary: The study reveals that formative stem (FS) cells, a novel type of stem cells, can directly respond to germ cell induction and differentiate into somatic tissues and germline in chimeras. Unlike embryonic stem cells (ESCs) or epiblast-derived stem cells (EpiSCs), FS cells exhibit distinct transcription factor dependencies, primarily relying on Otx2.

CELL STEM CELL (2021)

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Article Cell Biology

Formative pluripotent stem cells show features of epiblast cells poised for gastrulation

Xiaoxiao Wang et al.

Summary: This study reported the establishment of self-renewing formative pluripotent stem cells (fPSCs) that exhibit features of epiblast cells poised for gastrulation, and can be derived from different cell sources. fPSCs show distinct transcriptomic features of formative pluripotency compared to naive ESCs and primed EpiSCs, and have unique epigenetic states similar to E6.5 epiblast cells.

CELL RESEARCH (2021)

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Article Cell Biology