New scavenger to fine-tune insulin action in β cells

Insulin receptor signaling is crucial for beta cell homeostasis. In a recent issue of Nature, Ansarullah et al. (2021) have identified the insulin inhibitory receptor (inceptor), which balances insulin signaling by promoting insulin receptor internalization.

Automated summary

The study identified a new insulin inhibitory receptor, inceptor, which balances insulin signaling by promoting insulin receptor internalization, playing a crucial role in maintaining beta cell homeostasis.