期刊
CELL HOST & MICROBE
卷 29, 期 5, 页码 806-+出版社
CELL PRESS
DOI: 10.1016/j.chom.2021.04.005
关键词
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资金
- Bill and Melinda Gates Foundation [OPP1170236, INV-004923]
- NIH [R00 AI139445, R01 AI132317]
- GermanResearch Foundation
- Netherlands Organization for Scientific Research (NWO)
- DOE Office of Science [DE-AC02-06CH11357]
- Coronavirus CARES Act.
This study presents a cross-neutralizing antibody, CV38-142, which can accommodate antigenic variation in SARS-related viruses, providing valuable information for addressing current and future antigenic drift in SARS-CoV-2 and protecting against zoonotic SARS-related coronaviruses.
Coronaviruses have caused several human epidemics and pandemics including the ongoing coronavirus disease 2019 (COVID-19). Prophylactic vaccines and therapeutic antibodies have already shown striking effectiveness against COVID-19. Nevertheless, concerns remain about antigenic drift in SARS-CoV-2 as well as threats from other sarbecoviruses. Cross-neutralizing antibodies to SARS-related viruses provide opportunities to address such concerns. Here, we report on crystal structures of a cross-neutralizing antibody, CV38-142, in complex with the receptor-binding domains from SARS-CoV-2 and SARS-CoV. Recognition of the N343 glycosylation site and water-mediated interactions facilitate cross-reactivity of CV38-142 to SARS-related viruses, allowing the antibody to accommodate antigenic variation in these viruses. CV38-142 synergizes with other cross-neutralizing antibodies, notably COVA1-16, to enhance neutralization of SARS-CoV and SARS-CoV-2, including circulating variants of concern B.1.1.7 and B.1.351. Overall, this study provides valuable information for vaccine and therapeutic design to address current and future antigenic drift in SARS-CoV-2 and to protect against zoonotic SARS-related coronaviruses.
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