Nature or nurture: Factors that influence bnAb development

Article Multidisciplinary Sciences

Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth

Ryan S. Roark et al.

Summary: Research has shown that in rhesus macaques, primary HIV-1 envelope proteins can trigger patterns of coevolution with antibodies similar to those observed in humans, providing precise solutions for virus persistence. These findings can guide the design of HIV-1 vaccines by recapitulating the developmental features of human broadly neutralizing antibodies.

SCIENCE (2021)

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Article Microbiology

B cell engagement with HIV-1 founder virus envelope predicts development of broadly neutralizing antibodies

Samantha M. Townsley et al.

Summary: This study identified key B cell determinants within the first 14-43 days of viremia that predict the development of broadly neutralizing antibodies years later. The initial interaction between B cells and the founder HIV Env is crucial for the development of bNAbs. These findings suggest that events during HIV acute infection can impact downstream functional outcomes.

CELL HOST & MICROBE (2021)

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Article Medicine, General & Internal

Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition

L. Corey et al.

Summary: The study found that broadly neutralizing antibodies did not prevent HIV-1 acquisition more effectively than placebo, but analyses of VRC01-sensitive HIV-1 isolates indicated that prophylaxis with broadly neutralizing antibodies may be effective.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Review Immunology