Nature or nurture: Factors that influence bnAb development

The stochastic development of broadly neutralizing antibodies (bnAbs) to HIV-1 is influenced by complex viral and host interactions. In this issue of Cell Host & Microbe, Townsley et al. reveal that early B cell and virus interactions during acute infection are predictive for developing bnAb responses later in infection.

Automated summary

The development of broadly neutralizing antibodies to HIV-1 is influenced by complex viral and host interactions. Early interactions between B cells and the virus during acute infection are predictive of later bnAb responses.