相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。The repertoire of mutational signatures in human cancer
Ludmil B. Alexandrov et al.
NATURE (2020)
Helicobacter pylori CagA oncoprotein interacts with SHIP2 to increase its delivery into gastric epithelial cells
Yumiko Fujii et al.
CANCER SCIENCE (2020)
Bacterial CagA protein compromises tumor suppressor mechanisms in gastric epithelial cells
Manikandan Palrasu et al.
JOURNAL OF CLINICAL INVESTIGATION (2020)
H. pylori infection alters repair of DNA double-strand breaks via SNHG17
Taotao Han et al.
JOURNAL OF CLINICAL INVESTIGATION (2020)
The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress
Michael Bauer et al.
NATURE COMMUNICATIONS (2020)
Cholesteryl α-D-glucoside 6-acyltransferase enhances the adhesion of Helicobacter pylori to gastric epithelium
Hau-Ming Jan et al.
COMMUNICATIONS BIOLOGY (2020)
High-Molecular-Weight Hyaluronan Is a Hippo Pathway Ligand Directing Cell Density-Dependent Growth Inhibition via PAR1b
Takuya Ooki et al.
DEVELOPMENTAL CELL (2019)
Defining and Modulating 'BRCAness'
Andrea K. Byrum et al.
TRENDS IN CELL BIOLOGY (2019)
Inhibition of polarity-regulating kinase PAR1b contributes to Helicobacter pylori inflicted DNA Double Strand Breaks in gastric cells
Andrea Zamperone et al.
CELL CYCLE (2019)
Advances in understanding DNA processing and protection at stalled replication forks
Kimberly Rickman et al.
JOURNAL OF CELL BIOLOGY (2019)
Strelka2: fast and accurate calling of germline and somatic variants
Sangtae Kim et al.
NATURE METHODS (2018)
Helicobacter pylori Therapy for the Prevention of Metachronous Gastric Cancer
Il Ju Choi et al.
NEW ENGLAND JOURNAL OF MEDICINE (2018)
The Ambivalent Function of YAP in Apoptosis and Cancer
Xianbin Zhang et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs
Anahita Javaheri et al.
NATURE MICROBIOLOGY (2017)
Helicobacter pylori exploits human CEACAMs via HopQ for adherence and translocation of CagA
Verena Koeniger et al.
NATURE MICROBIOLOGY (2017)
Germline Mutations in PALB2, BRCA1, and RAD51C, Which Regulate DNA Recombination Repair, in Patients With Gastric Cancer
Ruta Sahasrabudhe et al.
GASTROENTEROLOGY (2017)
Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins
Takeru Hayashi et al.
CELL REPORTS (2017)
The Role of CagA in the Gastric Biology of Helicobacter pylori
Steffen Backert et al.
CANCER RESEARCH (2016)
Replication fork stability confers chemoresistance in BRCA-deficient cells
Arnab Ray Chaudhuri et al.
NATURE (2016)
Impact of structural polymorphism for the Helicobacter pylori CagA oncoprotein on binding to polarity-regulating kinase PAR1b
Hiroko Nishikawa et al.
SCIENTIFIC REPORTS (2016)
A novel human gastric primary cell culture system for modelling Helicobacter pylori infection in vitro
Philipp Schlaermann et al.
GUT (2016)
In Vitro Expansion of Human Gastric Epithelial Stem Cells and Their Responses to Bacterial Infection
Sina Bartfeld et al.
GASTROENTEROLOGY (2015)
Helicobacter pylori Activates and Expands Lgr5+ Stem Cells Through Direct Colonization of the Gastric Glands
Michael Sigal et al.
GASTROENTEROLOGY (2015)
Loss-of-function variants in ATM confer risk of gastric cancer
Hannes Helgason et al.
NATURE GENETICS (2015)
A mutational signature in gastric cancer suggests therapeutic strategies
Ludmil B. Alexandrov et al.
NATURE COMMUNICATIONS (2015)
Mutual reinforcement of inflammation and carcinogenesis by the Helicobacter pylori CagA oncoprotein
Nobumi Suzuki et al.
SCIENTIFIC REPORTS (2015)
Helicobacter pylori Infection Causes Characteristic DNA Damage Patterns in Human Cells
Max Koeppel et al.
CELL REPORTS (2015)
H. pylori-Induced DNA Strand Breaks Are Introduced by Nucleotide Excision Repair Endonucleases and Promote NF-κB Target Gene Expression
Mara L. Hartung et al.
CELL REPORTS (2015)
Hereditary Diffuse Gastric Cancer Syndrome CDH1 Mutations and Beyond
Samantha Hansford et al.
JAMA ONCOLOGY (2015)
Global burden of gastric cancer attributable to Helicobacter pylori
Martyn Plummer et al.
INTERNATIONAL JOURNAL OF CANCER (2015)
Helicobacter pylori CagA and Gastric Cancer: A Paradigm for Hit-and-Run Carcinogenesis
Masanori Hatakeyama
CELL HOST & MICROBE (2014)
Accumulation of Somatic Mutations in TP53 in Gastric Epithelium With Helicobacter pylori Infection
Takahiro Shimizu et al.
GASTROENTEROLOGY (2014)
Helicobacter pylori Infection Introduces DNA Double-Strand Breaks in Host Cells
Katsuhiro Hanada et al.
INFECTION AND IMMUNITY (2014)
Comprehensive molecular characterization of gastric adenocarcinoma
Adam J. Bass et al.
NATURE (2014)
Replication Stress-Induced Genome Instability: The Dark Side of Replication Maintenance by Homologous Recombination
Antony M. Carr et al.
JOURNAL OF MOLECULAR BIOLOGY (2013)
Signatures of mutational processes in human cancer
Ludmil B. Alexandrov et al.
NATURE (2013)
Multiplex Genome Engineering Using CRISPR/Cas Systems
Le Cong et al.
SCIENCE (2013)
Helicobacter pylori CagA: from pathogen mechanisms to its use as an anti-cancer vaccine
Markus Stein et al.
FRONTIERS IN IMMUNOLOGY (2013)
Tertiary Structure-Function Analysis Reveals the Pathogenic Signaling Potentiation Mechanism of Helicobacter pylori Oncogenic Effector CagA
Takeru Hayashi et al.
CELL HOST & MICROBE (2012)
Risk of cancer other than breast or ovarian in individuals with BRCA1 and BRCA2 mutations
A. Moran et al.
FAMILIAL CANCER (2012)
Helicobacter pylori stimulates epithelial cell migration via CagA-mediated perturbation of host cell signaling
Kenji Kikuchi et al.
MICROBES AND INFECTION (2012)
PAR-1/MARK: a Kinase Essential for Maintaining the Dynamic State of Microtubules
Kenji Hayashi et al.
CELL STRUCTURE AND FUNCTION (2011)
Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells
Isabella M. Toller et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Conversion of Helicobacter pylori CagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p21
Yasuhiro Saito et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates
Dragana Nesic et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)
Helicobacter pylori CagA Phosphorylation-Independent Function in Epithelial Proliferation and Inflammation
Masato Suzuki et al.
CELL HOST & MICROBE (2009)
Host Cell Interactome of Tyrosine-Phosphorylated Bacterial Proteins
Matthias Selbach et al.
CELL HOST & MICROBE (2009)
DNA Repair by Homologous Recombination, But Not by Nonhomologous End Joining, Is Elevated in Breast Cancer Cells
Zhiyong Mao et al.
NEOPLASIA (2009)
Analysis of detergent-resistant membranes of Helicobacter pylori infected gastric adenocarcinoma cells reveals a role for MARK2/Par1b in CagA-mediated disruption of cellular polarity
Zaher Zeaiter et al.
CELLULAR MICROBIOLOGY (2008)
Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer:: an open-label, randomised controlled trial
Kazutoshi Fukase et al.
LANCET (2008)
PML, YAP, and p73 Are Components of a Proapoptotic Autoregulatory Feedback Loop
Eleonora Lapi et al.
MOLECULAR CELL (2008)
Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse
Naomi Ohnishi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair
Nicole Bennardo et al.
PLOS GENETICS (2008)
A transgenic Drosophila model demonstrates that the Helicobacter pylori CagA protein functions as a eukaryotic Gab adaptor
Crystal M. Botham et al.
PLOS PATHOGENS (2008)
Helicobacter pylori CagA interacts with E-cadherin and deregulates the β-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells
N. Murata-Kamiya et al.
ONCOGENE (2007)
Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity
Iraj Saadat et al.
NATURE (2007)
Phosphatidylinositol 3-kinase/Akt signaling enhances nuclear localization and transcriptional activity of BRCA1
Cimona V. Hinton et al.
EXPERIMENTAL CELL RESEARCH (2007)
Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium
Yuko Matsumoto et al.
NATURE MEDICINE (2007)
Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo
Jonathan B. Hurov et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Expression of mutant type-p53 products in H pylori-associated chronic gastritis
Masaaki Kodama et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2007)
Structural basis and functional consequence of Helicobacter pylori CagA multimerization in cells
Shumei Ren et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Cholesterol glucosylation promotes immune evasion by Helicobacter pylori
Christian Wunder et al.
NATURE MEDICINE (2006)
Regulation of BRICA1, BRCA2 and BARD1 intracellular trafficking
BR Henderson
BIOESSAYS (2005)
Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation
H Higashi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Oncogenic mechanisms of the Helicobacter pylori CagA protein
M Hatakeyama
NATURE REVIEWS CANCER (2004)
Molecular biology of gastric cancer:: Helicobacter infection and gastric adenocarcinoma:: bacterial and host factors responsible for altered growth signaling
C Stoicov et al.
GENE (2004)
Hallmarks of 'BRCAness' in sporadic cancers
N Turner et al.
NATURE REVIEWS CANCER (2004)
Detection of p53 mutations in precancerous gastric tissue
C Morgan et al.
BRITISH JOURNAL OF CANCER (2003)
Attenuation of Helicobacter pylori CagA-SHP-2 signaling by interaction betwwen CagA and C-terminal Src kinase
R Tsutsumi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites
H Higashi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
BRCA2 gene mutations in families with aggregations of breast and stomach cancers
A Jakubowska et al.
BRITISH JOURNAL OF CANCER (2002)
Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: A tool for temporally regulated gene activation/inactivation in the mouse
S Hayashi et al.
DEVELOPMENTAL BIOLOGY (2002)
SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein
H Higashi et al.
SCIENCE (2002)
The BRCA1 suppressor hypothesis: An explanation for the tissue-specific tumor development in BRCA1 patients
SJ Elledge et al.
CANCER CELL (2002)
Helicobacter pylori in gastric cancer established by CagA immunoblot as a marker of past infection
AM Ekström et al.
GASTROENTEROLOGY (2001)