期刊
CELL
卷 184, 期 6, 页码 1517-1529出版社
CELL PRESS
DOI: 10.1016/j.cell.2021.01.042
关键词
-
资金
- NIH [K08 DK122130, T32HL105323, AI128949, AI06697, AI100119, AI150680, HL145547]
- Gerstner Family Foundation
This article explores the influence of various stressors on tissue immune responses, proposes potential strategies for targeting tissue immunity, and highlights areas of investigation needed to elucidate mechanisms for adaptation and restoration of homeostasis.
Our immune system has evolved to protect us from pathogens and maintain homeostasis through localization in diverse tissue sites throughout the body. Immune responses are orchestrated by T cells, which direct pathogen clearance at the infection site and establish tissue-resident memory T cells (TRMs) for protection immunity. Here, we discuss how tissue immune responses are influenced by various stressors (e.g., metabolic, environmental, aging) that are rapidly changing due to climate fluctuations and globalization. We propose potential strategies for targeting tissue immunity to mitigate future pathogenic and environmental challenges and areas of investigation that can elucidate mechanisms for adapting and restoring homeostasis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据