In this issue of Cell, Nunez et al. introduce CRISPRoff, a programmable epigenetic memory writer that establishes specific gene silencing programs stably maintained across cell division and differentiation. The singular dCas9 fusion provides a simple, reliable, and general tool for genome-wide screens, multiplexed editing, and potential therapeutics.
In this issue of Cell, Nunez et al. develop CRISPRoff, a programmable epigenetic memory writer capable of establishing specific gene silencing programs that are stably maintained across cell division and differentiation. The singular dCas9 fusion offers a simple, reliable, and general tool for genome-wide screens, multiplexed editing, and potential therapeutics.
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