期刊
CATALYSIS COMMUNICATIONS
卷 152, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.catcom.2021.106289
关键词
Aspergillus niger; Lipase; Biocatalysis; Kojic acid derivatives
资金
- Department of Science and Technology under FIST Programme and Special Assistance Programme (SAP) of University Grants Commission, New Delhi
- Rajiv Gandhi Science & Technology Commission, Government of Maharashtra
A novel biosynthetic route for the synthesis of kojic acid derivatives was developed efficiently with the use of lipase from Aspergillus niger, achieving high conversion rates (82-95%) in aqueous medium. The lipase was reused for three consecutive cycles without significant loss of activity, indicating the potential of this bioprocess to replace chemical catalytic processes.
The first efficient biocatalytic route for the synthesis of kojic acid derivatives was developed in presence of an enzyme. In this process, benzaldehydes, malononitrile and kojic acid were used as starting materials while lipase from Aspergillus niger was the promiscuous biocatalyst giving high conversion (82-95%) of kojic acid derivatives in aqueous medium. The probable enzymatic mechanism is proposed here. The lipase was reused till three consecutive cycles without a significant loss of activity. This efficient bioprocess has potential to replace the existing chemical catalytic processes to produce heterocyclic anti-tyrosinase compounds that prevents hyperpigmentation.
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