期刊
CARDIOVASCULAR RESEARCH
卷 118, 期 3, 页码 686-715出版社
OXFORD UNIV PRESS
DOI: 10.1093/cvr/cvab120
关键词
Diabetes; Diabetic cardiomyopathy; Heart failure; Mitochondria; Energy metabolism
资金
- Canadian Institutes of Health Research
- Alberta Innovates Postgraduate Fellowship in Health Innovation
- CIHR Canadian Graduate Doctoral Scholarship
- Izaak Walton Killam Memorial Scholarship
- Alberta Innovates Graduate Studentship
- Sir Frederick Banting and Dr. Charles Best Canada Graduate Scholarship-Masters from the Canadian Institutes of Health Research
- Walter H Johns Graduate Fellowship from the University of Alberta
- Maternal and Child Health scholarship (MatCH) programme
- Alberta Diabetes Institutes studentship
Diabetes increases the risk of heart failure, with both diseases exacerbating cardiovascular outcomes and progression. Factors contributing to diabetic cardiomyopathies are not fully understood.
Diabetes mellitus increases the risk of developing heart failure, and the co-existence of both diseases worsens cardiovascular outcomes, hospitalization, and the progression of heart failure. Despite current advancements on therapeutic strategies to manage hyperglycaemia, the likelihood of developing diabetes-induced heart failure is still significant, especially with the accelerating global prevalence of diabetes and an ageing population. This raises the likelihood of other contributing mechanisms beyond hyperglycaemia in predisposing diabetic patients to cardiovascular disease risk. There has been considerable interest in understanding the alterations in cardiac structure and function in diabetic patients, collectively termed as 'diabetic cardiomyopathy'. However, the factors that contribute to the development of diabetic cardiomyopathies are not fully understood. This review summarizes the main characteristics of diabetic cardiomyopathies, and the basic mechanisms that contribute to its occurrence. This includes perturbations in insulin resistance, fuel preference, reactive oxygen species generation, inflammation, cell death pathways, neurohormonal mechanisms, advanced glycated end-products accumulation, lipotoxicity, glucotoxicity, and post-translational modifications in the heart of the diabetic. This review also discusses the impact of antihyperglycaemic therapies on the development of heart failure, as well as how current heart failure therapies influence glycaemic control in diabetic patients. We also highlight the current knowledge gaps in understanding how diabetes induces heart failure.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据