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Role of LncRNAs in regulating cancer amino acid metabolism

期刊

CANCER CELL INTERNATIONAL
卷 21, 期 1, 页码 -

出版社

BMC
DOI: 10.1186/s12935-021-01926-8

关键词

lncRNA; Metabolism; Amino acid; Glutamine; Cancer

类别

资金

  1. National Natural Science Foundation of China [81672866, 81960501, 81560452]
  2. Natural Science Foundation of Jiangxi Province [20161BAB205192, 20171ACB21073]
  3. Natural Science Foundation of Jiangxi Province the Youth Science Foundation of Jiangxi Province [20122BAB215028]

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Tumor cells undergo metabolic reprogramming involving crucial roles of amino acid metabolism in cancer progression, with long non-coding RNAs being key players in cancer tissues and partaking in regulation by interacting with other macromolecular substances.
The metabolic change of tumor cells is an extremely complicated process that involves the intersection and integration of various signal pathways. Compared with normal tissues, cancer cells show distinguished metabolic characteristics called metabolic reprogramming, which has been considered as a sign of cancer occurrence. With the deepening of tumor research in recent years, people gradually found that amino acid metabolism played crucial roles in cancer progression. Long non-coding RNAs (lncRNAs), which are implicated in many important biological processes, were firstly discovered dysregulating in cancer tissues and participating in extensive regulation of tumorigenesis. This review focuses on the reprogramming of amino acid metabolism in cancers and how lncRNAs participate in the regulatory network by interacting with other macromolecular substances. Understanding the functions of lncRNA in amino acid reprogramming in tumors might provide a new vision on the mechanisms of tumorigenesis and the development of new approaches for cancer therapy.

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