A large-scale snapshot of intratumor heterogeneity in human cancer

Using sophisticated statistical analyses on population-scale cancer whole-genome sequences, a new study published in Cell characterizes the genomic architecture of intratumor heterogeneity (ITH). It results in an unprecedented snapshot of subclones in about 30 cancer types, generating a wealth of insight into the underlying mutational events, processes, and their selection.

Automated summary

The study utilizes sophisticated statistical analyses on population-scale cancer whole-genome sequences to characterize the genomic architecture of intratumor heterogeneity, providing unprecedented insights into subclones in about 30 cancer types.