4.6 Review

Recent Progress Toward Clinical Translation of Tissue- Engineered Heart Valves

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Summary: The embryonic endocardium plays a vital role in early heart development by inducing the formation of trabecular myocardium, the source of valvular cells and part of the coronary vasculature. Human endocardial cells offer unique therapeutic opportunities, such as engineering biological valves and cell-based therapy for damaged hearts. By generating hPSC-derived endothelial cells, key signaling pathways for the development of endocardial cells were identified, with a novel role for BMP10 in lineage specification.

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Summary: This study aimed to establish methods for isolating, expanding, and promoting ECM synthesis by pUCPVCs as a relevant preclinical model for engineered heart valves. The results demonstrated the potential of pUCPVCs to synthesize key ECM components of heart valves under specific culture conditions, providing protocols for the use of pUCPVCs as a viable cell source for preclinical testing.

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