期刊
EPL
卷 115, 期 6, 页码 -出版社
EPL ASSOCIATION, EUROPEAN PHYSICAL SOCIETY
DOI: 10.1209/0295-5075/115/68006
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资金
- NSF [DMR-1554716, DMR-1206332]
- Alfred P. Sloan Research Fellowship in Physics
- James H. Zumberge Faculty Research and Innovation Fund at USC
- USC Center for High-Performance Computing
- Kavli Institute for Theoretical Physics, Santa Barbara, via NSF award [PHY-1125915]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1554716, 1206332] Funding Source: National Science Foundation
Motivated by single-molecule experiments on synaptic membrane protein domains, we use a stochastic lattice model to study protein reaction and diffusion processes in crowded membranes. We find that the stochastic reaction-diffusion dynamics of synaptic proteins provide a simple physical mechanism for collective fluctuations in synaptic domains, the molecular turnover observed at synaptic domains, key features of the single-molecule trajectories observed for synaptic proteins, and spatially inhomogeneous protein lifetimes at the cell membrane. Our results suggest that central aspects of the single-molecule and collective dynamics observed for membrane protein domains can be understood in terms of stochastic reaction-diffusion processes at the cell membrane. Copyright (C) EPLA, 2016.
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