期刊
BRAIN STRUCTURE & FUNCTION
卷 226, 期 5, 页码 1389-1403出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00429-020-02200-9
关键词
Parkinson’ s disease; Early-stage; MRI; Graph theory; Brain network; Psychoradiology
资金
- National Natural Science Foundation of China [81621003, 81820108018, 82001800]
- Sichuan Science and Technology Program [2018HH0077]
- China Postdoctoral Science Foundation [2020M683317]
- West China Hospital, Sichuan University [2019HXBH104]
This study found disruptions in the topological organization of GM networks in early-stage PD, suggesting greater segregation of information processing. These findings have potential application in early imaging diagnosis.
While previous structural-covariance studies have an advanced understanding of brain alterations in Parkinson's disease (PD), brain-behavior relationships have not been examined at the individual level. This study investigated the topological organization of grey matter (GM) networks, their relation to disease severity, and their potential imaging diagnostic value in PD. Fifty-four early-stage PD patients and 54 healthy controls (HC) underwent structural T1-weighted magnetic resonance imaging. GM networks were constructed by estimating interregional similarity in the distributions of regional GM volume using the Kullback-Leibler divergence measure. Results were analyzed using graph theory and network-based statistics (NBS), and the relationship to disease severity was assessed. Exploratory support vector machine analyses were conducted to discriminate PD patients from HC and different motor subtypes. Compared with HC, GM networks in PD showed a higher clustering coefficient (P = 0.014) and local efficiency (P = 0.014). Locally, nodal centralities in PD were lower in postcentral gyrus and temporal-occipital regions, and higher in right superior frontal gyrus and left putamen. NBS analysis revealed decreased morphological connections in the sensorimotor and default mode networks and increased connections in the salience and frontoparietal networks in PD. Connection matrices and graph-based metrics allowed single-subject classification of PD and HC with significant accuracy of 73.1 and 72.7%, respectively, while graph-based metrics allowed single-subject classification of tremor-dominant and akinetic-rigid motor subtypes with significant accuracy of 67.0%. The topological organization of GM networks was disrupted in early-stage PD in a way that suggests greater segregation of information processing. There is potential for application to early imaging diagnosis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据