4.5 Article

Simultaneous spatial-temporal decomposition for connectome-scale brain networks by deep sparse recurrent auto-encoder

期刊

BRAIN IMAGING AND BEHAVIOR
卷 15, 期 5, 页码 2646-2660

出版社

SPRINGER
DOI: 10.1007/s11682-021-00469-w

关键词

Task-based fMRI; Deep sparse recurrent auto-encoder; Spatial-temporal

资金

  1. National Natural Science Foundation of China [61876021]
  2. Beijing Municipal Natural Science Foundation [4212037]
  3. China Scholarships Council [201806040083]
  4. National Institutes of Health [DA033393, AG042599]
  5. National Science Foundation [IIS-1149260, CBET-1302089, BCS-1439051, DBI1564736]

向作者/读者索取更多资源

The study proposed a deep sparse recurrent auto-encoder (DSRAE) for unsupervised learning of spatial patterns and temporal fluctuations of brain networks simultaneously. The proposed model was evaluated on tasks from the HCP fMRI dataset, showing promising evidence of its effectiveness.
Exploring the spatial patterns and temporal dynamics of human brain activity has been of great interest, in the quest to better understand connectome-scale brain networks. Though modeling spatial and temporal patterns of functional brain networks have been researched for a long time, the development of a unified and simultaneous spatial-temporal model has yet to be realized. For instance, although some deep learning methods have been proposed recently in order to model functional brain networks, most of them can only represent either spatial or temporal perspective of functional Magnetic Resonance Imaging (fMRI) data and rarely model both domains simultaneously. Due to the recent success in applying sequential auto-encoders for brain decoding, in this paper, we propose a deep sparse recurrent auto-encoder (DSRAE) to be applied unsupervised to learn spatial patterns and temporal fluctuations of brain networks at the same time. The proposed DSRAE was evaluated and validated based on three tasks of the publicly available Human Connectome Project (HCP) fMRI dataset, resulting with promising evidence. To the best of our knowledge, the proposed DSRAE is among the early efforts in developing unified models that can extract connectome-scale spatial-temporal networks from 4D fMRI data simultaneously.

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