期刊
EPILEPSY & BEHAVIOR
卷 55, 期 -, 页码 170-173出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yebeh.2015.12.009
关键词
SUDEP; Insula; Heart rate variability; Autonomic; Parasympathetic; Postictal bradycardia
资金
- Center for SUDEP Research: NIH/NINDS [U01-NS090405-01, U01-NS090407-01]
We analyzed the only two sudden unexpected death in epilepsy (SUDEP) cases from 320 prospectively recruited patients in the three-year Prevention and Risk Identification of SUDEP Mortality (PRISM) project. Both patients had surgically refractory epilepsy, evidence of left insular damage following previous temporal/temporo-insular resections, and progressive changes in heart rate variability (HRV) in monitored evaluations prior to death. Insular damage is known to cause autonomic dysfunction and increased mortality in acute stroke. This report suggests a possible role for the insula in the pathogenesis of SUDEP. The presence of intrinsic insular lesions or acquired insular damage in patients with refractory epilepsy may be an additional risk factor for SUDEP. (C) 2015 Elsevier Inc. All rights reserved.
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